The Role of Lipids in Cancer
In cancer, there is overactivation of lipogenesis. The mechanisms through which lipids mediate oncogenes and pathogenesis are largely unknown. Our lab is focused on developing mass spectrometry instrumentation and methods that enable the identification of lipid biomarkers of oncogene expression, cancer phenotypes, and disease states in monolayer and suspension breast cancer cell cultures.
- Heather M. Robison, Corryn E. Chini, Troy J. Comi, Seung Woo Ryu, Elaine Ognjanovski, and Richard H. Perry*, Identification of lipid biomarkers of metastatic potential and gene expression (HER2/p53) in human breast cancer cell cultures using ambient mass spectrometry, Anal. Bioanal. Chem., 2020, 412, 2949-2961. DOI: https://doi.org/10.1007/s00216-020-02537-4